Detection of a gene cluster that is dispensable for human herpesvirus 6 replication and latency.

نویسندگان

  • Kazuhiro Kondo
  • Hideo Nozaki
  • Kazuya Shimada
  • Koichi Yamanishi
چکیده

The U3-U7 gene cluster of human herpesvirus 6 (HHV-6) was replaced with an enhanced green fluorescent protein-puromycin gene cassette containing the cytomegalovirus major immediate-early promoter. Neither viral replication in T cells nor latency and reactivation in macrophages was impaired. During HHV-6 latency, the cytomegalovirus promoter used the transcription start sites employed in cytomegalovirus latency.

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عنوان ژورنال:
  • Journal of virology

دوره 77 19  شماره 

صفحات  -

تاریخ انتشار 2003